Electronic switching circuit uses complementary non-linear components

Inherent switching properties of saturable inductors and storage diodes are combined to perform large variety of electronic functions, such as pulse shaping, gating, and multiplexing. Passive elements replace active switching devices in generation of complex waveforms

Caged calcium in Aplysia pacemaker neurons. Characterization of calcium-activated potassium and nonspecific cation currents.

We have studied calcium-activated potassium current, IK(Ca), and calcium-activated nonspecific cation current, INS(Ca), in Aplysia bursting pacemaker neurons, using photolysis of a calcium chelator (nitr-5 or nitr-7) to release caged calcium intracellularly. A computer model of nitr photolysis, multiple buffer equilibration, and active calcium extrusion was developed to predict volume-average and front-surface calcium concentration transients. Changes in arsenazo III absorbance were used to measure calcium concentration changes caused by nitr photolysis in microcuvettes. Our model predicted the calcium increments caused by successive flashes, and their dependence on calcium loading, nitr concentration, and light intensity. Flashes also triggered the predicted calcium concentration jumps in neurons filled with nitr-arsenazo III mixtures. In physiological experiments, calcium-activated currents were recorded under voltage clamp in response to flashes of different intensity. Both IK(Ca) and INS(Ca) depended linearly without saturation upon calcium concentration jumps of 0.1-20 microM. Peak membrane currents in neurons exposed to repeated flashes first increased and then declined much like the arsenazo III absorbance changes in vitro, which also indicates a first-order calcium activation. Each flash-evoked current rose rapidly to a peak and decayed to half in 3-12 s. Our model mimicked this behavior when it included diffusion of calcium and nitr perpendicular to the surface of the neuron facing the flashlamp. Na/Ca exchange extruding about 1 pmol of calcium per square centimeter per second per micromolar free calcium appeared to speed the decline of calcium-activated membrane currents. Over a range of different membrane potentials, IK(Ca) and INS(Ca) decayed at similar rates, indicating similar calcium stoichiometries independent of voltage. IK(Ca), but not INS(Ca), relaxes exponentially to a different level when the voltage is suddenly changed. We have estimated voltage-dependent rate constants for a one-step first-order reaction scheme of the activation of IK(Ca) by calcium. After a depolarizing pulse, INS(Ca) decays at a rate that is well predicted by a model of diffusion of calcium away from the inner membrane surface after it has entered the cell, with active extrusion by surface pumps and uptake into organelles. IK(Ca) decays somewhat faster than INS(Ca) after a depolarization, because of its voltage-dependent relaxation combined with the decay of submembrane calcium. The interplay of these two currents accounts for the calcium-dependent outward-inward tail current sequence after a depolarization, and the corresponding afterpotentials after a burs

The Institutionalization of Institutional Theory

[Excerpt] Our primary aims in this effort are twofold: to clarify the independent theoretical contributions of institutional theory to analyses of organizations, and to develop this theoretical perspective further in order to enhance its use in empirical research. There is also a more general, more ambitious objective here, and that is to build a bridge between two distinct models of social actor that underlie most organizational analyses, which we refer to as a rational actor model and an institutional model. The former is premised on the assumption that individuals are constantly engaged in calculations of the costs and benefits of different action choices, and that behavior reflects such utility-maximizing calculations. In the latter model, by contrast, \u27oversocialized\u27 individuals are assumed to accept and follow social norms unquestioningly, without any real reflection or behavioral resistance based on their own particular, personal interests. We suggest that these two general models should be treated not as oppositional but rather as representing two ends of a continuum of decision-making processes and behaviors. Thus, a key problem for theory and research is to specify the conditions under which behavior is more likely to resemble one end of this continuum or the other. In short, what is needed are theories of when rationality is likely to be more or less bounded. A developed conception of institutionalization processes provides a useful point of departure for exploring this issue

The application of integral performance criteria to the analysis of discrete maneuvers in a driving simulator

The influence of vehicle transient response characteristics on driver-vehicle performance in discrete maneuvers as measured by integral performance criteria was investigated. A group of eight ordinary drivers was presented with a series of eight vehicle transfer function configurations in a driving simulator. Performance in two discrete maneuvers was analyzed by means of integral performance criteria. Results are presented

Lp-cohomology of negatively curved manifolds

We compute the $L^p$-cohomology spaces of some negatively curved manifolds. We deal with two cases: manifolds with finite volume and sufficiently pinched negative curvature, and conformally compact manifolds

A topological realization of the congruence subgroup Kernel A

A number of years ago, Kumar Murty pointed out to me that the computation of the fundamental group of a Hilbert modular surface ([7],IV,${\S}$6), and the computation of the congruence subgroup kernel of SL(2) ([6]) were surprisingly similar. We puzzled over this, in particular over the role of elementary matrices in both computations. We formulated a very general result on the fundamental group of a Satake compactification of a locally symmetric space. This lead to our joint paper [1] with Lizhen Ji and Les Saper on these fundamental groups. Although the results in it were intriguingly similar to the corresponding calculations of the congruence subgroup kernel of the underlying algebraic group in [5], we were not able to demonstrate a direct connection (cf. [1], ${\S}$7). The purpose of this note is to explain such a connection. A covering space is constructed from inverse limits of reductive Borel-Serre compactifications. The congruence subgroup kernel then appears as the group of deck transformations of this covering. The key to this is the computation of the fundamental group in [1]

Dynamics of Special Points on Intermediate Jacobians

We prove some general density statements about the subgroup of invertible points on intermediate jacobians; namely those points in the Abel-Jacobi image of nullhomologous algebraic cycles on projective algebraic manifolds.Comment: 10 page